Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon

摘要: Mucin 16 (cancer antigen 125) is a cell surface glycoprotein that plays role in promoting cancer growth ovarian cancer. The aims of this study were to examine mucin expression large number digestive tract adenocarcinomas and precursors determine whether up-regulation correlated with patient outcome. Tissue microarrays constructed using surgical resection tissues included pancreatic (115 normal, 29 precursors, 200 ductal adenocarcinomas), esophageal (86 104 95 adenocarcinomas, 35 lymph node metastases), gastric (211 8 119 62 colorectal (34 17 39 adenocarcinomas) tissues. was detected 81.5%, 69.9%, 41.2%, 64.1% the respectively. seen subset precursors. On multivariate analysis, moderate/diffuse strongly associated poor survival (P < .001), independent other prognosis predictors. A similar trend observed for = .160) .080). Focal significantly .044) better outcome, when compared 16–negative cases. Using Western blot we found 3 6 adenocarcinoma 1 2 lines. We conclude most their express 16. an predictor outcome potentially adenocarcinomas. propose may function as prognostic marker therapeutic target future.