Effects of teriparatide retreatment in a patient with β‐thalassemia major

摘要: BACKGROUND Bone disease is a frequent complication of β-thalassemia major (β-ΤΜ) and its etiology multifactorial. Marrow expansion, chronic hypoxia, endocrine complications, iron overload caused chiefly by transfusion treatment are significant factors affecting skeletal health. Bone prevalent even among patients on regular transfusions adequate chelation. The life expectancy with has increased during the past decade so, nowadays, thalassemia-associated bone (TBD) often require long-term management. There limited data concerning their pharmacologic treatment. Bisphosphonates represent most widely studied agents in such there no published studies about effects anabolic Retreatment teriparatide only occasionally been osteoporosis. CASE REPORT We present male adult patient β-ΤΜ history low mass multiple vertebral fractures, who required sequential for his longstanding disease. He had exhibited considerable, albeit delayed, response to course 18 months but subsequently, while alendronate, sustained an insufficiency fracture at left ischiopubic ramus. A second trial resulted further remarkable increase total hip femoral neck mineral density. We patient's 8-year follow-up. CONCLUSION Teriparatide could alternative adults TBD especially when long-term, needed. Although retreatment, selected cases, this might be considered.