Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study.

摘要: β-Thalassemia major causes ineffective erythropoiesis and chronic anemia is associated with iron overload due to both transfused increased absorption, the latter mediated by suppression of iron-regulatory hormone hepcidin. We sought determine whether, in β-thalassemia major, transfusion-mediated inhibition dynamically affects recruited 31 chronically patients collected samples immediately before 4 8 days after transfusion. Pretransfusion hepcidin was positively correlated hemoglobin ferritin inversely erythropoiesis. The hepcidin-ferritin ratio indicated relatively suppressed given degree loading. Posttransfusion, increased, erythropoietin growth differentiation factor-15 decreased. By multiple regression, pre- posttransfusion concentrations were hemoglobin, erythropoiesis, ferritin. Although men women had similar pretransfusion significantly lower hepcidin, received a transfusion volume per liter blood volume, experienced smaller reduction rise. Age not or change. Hepcidin levels reflect competing influences from anemia, overload. Measurement these indices could assist clinical monitoring.