Hemophore-Dependent Heme Acquisition Systems

作者: Laurent Debarbieux , Cécile Wandersman

DOI: 10.1128/9781555816544.CH3

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摘要: This chapter describes hemophore secretion and its interaction with heme hemoproteins, specific receptors, mechanisms of transfer from to receptor, TonB function at various steps in the acquisition process, regulation has operon. HasA hemophores are secreted by ABC transporters. One four identified, Serratia marcescens protein, been biochemically characterized. The between receptor was first investigated binding experiments cells expressing HasR immobilized on nitrocellulose membranes. Second, whole liquid media determined. In a wider perspective, it would be interesting investigate whether hemophore-like proteins exist gram-positive bacteria species or used nonproducing bacteria, similarly certain siderophores. Finally, many bacterial have multiple systems, only one these being dependent. Hemophores enhance efficiency delivery enlarge source range.

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