Imatinib mesylate inhibits platelet-derived growth factor activity and increases chemosensitivity in feline vaccine-associated sarcoma
作者： Rieko Katayama , Michael K. Huelsmeyer , Amanda K. Marr , Ilene D. Kurzman , Douglas H. Thamm
DOI: 10.1007/S00280-004-0780-7
关键词:
摘要: Feline vaccine-associated sarcoma (VAS) is a biologically aggressive soft-tissue that can develop at sites where inactivated feline vaccines have been administered. We showed platelet-derived growth factor (PDGF) and its receptor (PDGFR) play role in the of VAS cells. The presence PDGFR-β was confirmed each five cell lines evaluated, one non-vaccine-associated fibrosarcoma (FSA) line fibroblast-derived line. PDGF/PDGFR signaling pathway inhibited FSA using tyrosine kinase inhibitor imatinib mesylate (formerly called STI-571). Imatinib PDGF-BB-induced autophosphorylation PDGFR cells vitro dose-dependent manner. also significantly tumors murine xenograft model. reversed protective effect PDGF-BB on inhibition by doxorubicin carboplatin. protected from serum starvation doxorubicin-induced apoptosis but not carboplatin-induced apoptosis, eliminated this protection. These observations suggest inhibits activity soft tissue sarcomas tumor
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