Treatment of cd47+ disease cells with sirp alpha-fc fusions
作者： Penka Slavtcheva Slavova-Petrova , Xinli Pang , Robert Adam Uger
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摘要: CD47+ disease cells, such as cancer are treated with an agent that blocks signalling via the SIRPα/CD47 axis. The is a human SIRPα fusion protein displays negligible CD47 agonism and red blood cell binding. comprises IgV domain from variant 2 of SIRPα, Fc having effector function. binds affinity at least five fold greater than entire extracellular region SIRPα. 5 more potent counterpart lacking
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