Augmented Mitotic Cell Count using Field Of Interest Proposal.

作者: Marc Aubreville , Christof A. Bertram , Robert Klopfleisch , Andreas Maier

DOI: 10.1007/978-3-658-25326-4_71

关键词:

摘要: Histopathological prognostication of neoplasia including most tumor grading systems are based upon a number criteria. Probably the important is mitotic figures which commonly determined as count (MC), i.e. within 10 consecutive high power fields. Often area with highest activity to be selected for MC. However, since not known in advance, an arbitrary choice this region considered one cause variability and grading. In work, we present algorithmic approach that first calculates cell map deep convolutional network. This second step used construct estimate. Lastly, select image segment representing size ten fields overall proposal expert MC determination. We evaluate using dataset 32 completely annotated whole slide images, where 22 were training network test. find correlation r=0.936

参考文章(12)
Dan C. Cireşan, Alessandro Giusti, Luca M. Gambardella, Jürgen Schmidhuber, Mitosis detection in breast cancer histology images with deep neural networks. medical image computing and computer-assisted intervention. ,vol. 16, pp. 411- 418 ,(2013) , 10.1007/978-3-642-40763-5_51
Philipp Fischer, Thomas Brox, None, U-Net: Convolutional Networks for Biomedical Image Segmentation medical image computing and computer assisted intervention. pp. 234- 241 ,(2015) , 10.1007/978-3-319-24574-4_28
Nobuyuki Otsu, A Threshold Selection Method from Gray-Level Histograms IEEE Transactions on Systems, Man, and Cybernetics. ,vol. 9, pp. 62- 66 ,(1979) , 10.1109/TSMC.1979.4310076
D. J. Meuten, F. M. Moore, J. W. George, Mitotic Count and the Field of View Area Time to Standardize Veterinary Pathology. ,vol. 53, pp. 7- 9 ,(2016) , 10.1177/0300985815593349
Md Atiqur Rahman, Yang Wang, Optimizing Intersection-Over-Union in Deep Neural Networks for Image Segmentation international symposium on visual computing. pp. 234- 244 ,(2016) , 10.1007/978-3-319-50835-1_22
Kyunghyun Paeng, Sangheum Hwang, Sunggyun Park, Minsoo Kim, A Unified Framework for Tumor Proliferation Score Prediction in Breast Histopathology DLMIA/ML-CDS@MICCAI. pp. 231- 239 ,(2017) , 10.1007/978-3-319-67558-9_27
Michael Bonert, Angela J. Tate, Mitotic counts in breast cancer should be standardized with a uniform sample area Biomedical Engineering Online. ,vol. 16, pp. 28- ,(2017) , 10.1186/S12938-016-0301-Z
Marc Aubreville, Christof Bertram, Robert Klopfleisch, Andreas Maier, SlideRunner - A Tool for Massive Cell Annotations in Whole Slide Images arXiv: Computer Vision and Pattern Recognition. ,(2018) , 10.1007/978-3-662-56537-7_81