Active patterning and asymmetric transport in a model actomyosin network

摘要: Cytoskeletal networks, which are essentially motor-filament assemblies, play a major role in many developmental processes involving structural remodeling and shape changes. These achieved by nonequilibrium self-organization that generate functional patterns drive intracellular transport. We construct minimal physical model incorporates the coupling between nonlinear elastic responses of individual filaments force-dependent motor action. By performing stochastic simulations we show interplay processes, described as driving anti-correlated motion network vertices, connectivity, determines percolation character structure, can indeed capture dynamical cooperativity gives rise to diverse observed experimentally. The buckling instability is found key localizing collapse events due local force imbalance. Motor-driven buckling-induced node aggregation provides dynamic mechanism stabilizes two dimensional below apparent static limit. Coordinated action also shown suppress random thermal noise on large time scales, configuration system starts with thus remaining planar during development. carrying out similar three anchored network, find myosin-driven isotropic contraction well-connected actin when combined mechanical anchoring confers directionality collective motion, may represent novel transport, revealed chromosome translocation starfish oocyte.