The role of the Arp2/3 complex in shaping the dynamics and structures of branched actomyosin networks.

摘要: Actomyosin networks give cells the ability to move and divide. These contract expand while being driven by active energy-consuming processes such as motor protein walking actin polymerization. Actin dynamics is also regulated actin-binding proteins, actin-related 2/3 (Arp2/3) complex. This complex generates branched filaments, thereby changing overall organization of network. In this work, spatiotemporal patterns dynamical assembly accompanying branching-induced reorganization caused Arp2/3 were studied using a computational model (mechanochemical [MEDYAN]); simulates actomyosin network result chemical reactions whose rates are modulated rapid mechanical equilibration. We show that relax significantly more slowly than do unbranched networks. Also, undergo rare convulsive movements, "avalanches," release strain in avalanches associated with heterogeneous distribution mechanically linked filaments displayed far-from-equilibrium events arising from marginal stability growing provide possible mechanism "cytoquakes" recently seen experiments.