Biomaterials for liver tissue engineering

摘要: Liver extracellular matrix (ECM) composition, topography and biomechanical properties influence cell-matrix interactions. The ECM presents guiding cues for hepatocyte phenotype maintenance, differentiation proliferation both in vitro vivo. Current understanding of such cell-guiding along with advancement techniques scaffold fabrication has led to evolution matrices liver tissue culture from simple porous scaffolds more complex 3D microarchitecture similar Natural synthetic polymeric biomaterials fabricated different topographies have been used culture. Heterotypic homotypic cell interactions are necessary developing an adult as well artificial liver. A high oxygen demand hepatocytes graded distribution is another challenging attribute the normal architecture that further adds complexity engineered substrate design. balanced interplay cell-cell adequate supply nutrient determines success cells. Techniques devised incorporate these features hepatic function mimic range maintaining cells mm-sized tailor-made a bottoms up approach starts building microscopic subunit whole tissue. In this review, we discuss briefly various engineering respect design parameters composition chemistry, properties, topography, oxygenation.