A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.

作者: Francesco A. Aprile , Pietro Sormanni , Michele Vendruscolo

DOI: 10.1021/ACS.BIOCHEM.5B00459

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摘要: … -Aβ) grafted to target Aβ inhibits α-synuclein aggregation in a … in the inhibitory effect on Aβ42 aggregation was observed for … -Aβ exhibits an enhanced ability to prevent Aβ aggregation (…

参考文章(65)
Bernd Bukau, Matthias P. Mayer, Hartwig Schröder, Stefan Rüdiger, Klaus Paal, Thomas Laufen, Multistep mechanism of substrate binding determines chaperone activity of Hsp70 Nature Structural & Molecular Biology. ,vol. 7, pp. 586- 593 ,(2000) , 10.1038/76819
Jose F. Abisambra, Umesh K. Jinwal, John Koren, Chad A. Dickey, Jeffrey R. Jones, John C. O’Leary, Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and Cellular Pharmacology. ,vol. 2, pp. 43- 46 ,(2010)
Dirk Brehmer, Stefan Rüdiger, Claudia S. Gässler, Dagmar Klostermeier, Lars Packschies, Jochen Reinstein, Matthias P. Mayer, Bernd Bukau, Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange Nature Structural & Molecular Biology. ,vol. 8, pp. 427- 432 ,(2001) , 10.1038/87588
Pietro Sormanni, Francesco A. Aprile, Michele Vendruscolo, Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 9902- 9907 ,(2015) , 10.1073/PNAS.1422401112
Mark S. Hipp, Sae-Hun Park, F. Ulrich Hartl, Proteostasis impairment in protein-misfolding and -aggregation diseases Trends in Cell Biology. ,vol. 24, pp. 506- 514 ,(2014) , 10.1016/J.TCB.2014.05.003
Paul J. Muchowski, Jennifer L. Wacker, Modulation of neurodegeneration by molecular chaperones Nature Reviews Neuroscience. ,vol. 6, pp. 11- 22 ,(2005) , 10.1038/NRN1587
Michel Goedert, Alpha-synuclein and neurodegenerative diseases. Nature Reviews Neuroscience. ,vol. 2, pp. 492- 501 ,(2001) , 10.1038/35081564
Tuomas P. J. Knowles, Michele Vendruscolo, Christopher M. Dobson, The amyloid state and its association with protein misfolding diseases Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 384- 396 ,(2014) , 10.1038/NRM3810
F. Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl, Molecular chaperones in protein folding and proteostasis Nature. ,vol. 475, pp. 324- 332 ,(2011) , 10.1038/NATURE10317