Kinetic analysis of tear interference images in aqueous tear deficiency dry eye before and after punctal occlusion.

摘要: PURPOSE: Kinetic analysis of sequential tear interference images was used to investigate how the precorneal lipid film spread and distributed in aqueous deficiency (ATD) dry eye. METHODS: One eye 17 patients with ATD randomly selected for this noncomparative case series. Twelve also had noninflamed meibomian gland dysfunction (MGD). Sequential were digitized analyzed on computer. Data further compared 9 cases before after punctal occlusion (PO). Outcome measures included speed pattern resultant layer thickness superior, central, inferior cornea. Intensity red/green/blue (RGB) color spectra image PO. RESULTS: After lid blinking, it took a longer time (2.2 +/- 1.1 second) reach stable all eyes normal subjects (P < 0.0001). Because retarded spread, thickest located at cornea adjacent margin, gradient spreading toward superior = 0.01). As result, thinner than 10 (59%) eyes. Fifteen (88%) showed vertical streaking, rather horizontal propagation Such lipid-deficient state uneven distribution did not correlate presence or absence MGD. The shortened 0.008), more even, approached nine CONCLUSIONS: In study, kinetic provided evidence that retardation is, but MGD is not, main reason increased ATD. deficient unevenly distributed, destabilizing film. fact PO significantly improves evenness, suggests performance dictated by amount fluid. These findings provide new insight into interaction between