Sequential changes of lipid tear film after the instillation of a single drop of a new emulsion eye drop in dry eye patients.

摘要: Abstract Purpose The lipid tear film stabilizes the tears by lowering surface tension and preventing aqueous evaporation may be analyzed kinetic analysis of interference images. This study investigated changes in after application a new emulsion-based eye drop Refresh Endura (Allergan, Irvine, CA) normal subjects patients with dry eyes. Design Comparative, nonrandomized interventional study. Participants Five 10 deficiency (ATD) or without were enrolled prospectively. Methods A complete examination was performed, including symptom score, break-up time, dye staining, fluorescein clearance test. One received single dose emulsion (EED), whereas other nonpreserved saline as control. Kinetic images taken DR-1 (Kowa, Japan) performed before at various times instillation drops. Main outcome measures Symptoms, pattern, thickness, spread time film. Results Compared control, all eyes receiving EED showed rapid restructuring preexisting In persons, resulted thick band across cornea significant increase thickness. For ATD patients, either scant, irregular film, which became covered modified changed forming irregularities. Emulsion drops tended to more comfortable severe ATD. that mean improved for when compared baseline controls ( P Conclusions produces patients. Further investigation prolonged period treatment is warranted establish whether help improve thickness moderate