The association of -308 TNFα polymorphism and multiple sclerosis in Iranian patients

摘要: " Multiple Sclerosis is a chronic neuro-immune disorder of the central CNS. MS belongs to large group multifactorial and multi-genic disease. The TNFα gene encodes pro-inflammatory cytokine that takes an ambiguous part in development various disorders especially autoimmune disease such as MS. In this study we investigated association -308A/G polymorphism multiple sclerosis Iranian patients. One hundred patients one ethnically, age sex matched healthy control individuals were selected. A (-308) was analyzed based on polymerase chain reaction with sequence-specific primers (developed during 13IHWC supplied by Heidelberg University (Heidelberg, Germany)). frequency G allele G/G genotype at -308 position significantly higher comparison subjects (OR: 1.685, 95%CI: 1.046–2.715, P: 0.041; OR: 1.933, 95% CI: 1.095–3.411, 0.032, respectively). It indicated had susceptibility effect among But more studies sample size specially investigation different alleles relation other genes haplotypes are needed explain exact polymorphisms MS."