MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1.
作者： Paula Mussnich , Roberta Rosa , Roberto Bianco , Alfredo Fusco , Daniela D’Angelo
DOI: 10.1517/14728222.2015.1057569
关键词:
摘要: Objectives: We aimed to analyze the differentially-expressed miRNAs in colon cancer cells order identify novel potential biomarkers involved cell resistance.Design and methods: investigated miRNA expression profile of GEO human carcinoma cells, sensitive EGFR inhibitor Cetuximab (CTX) their CTX-resistant counterpart (GEO CR) by using a chip.Results: found 27 upregulated 10 downregulated CR compared with fold change ≥ 2. Among miRNAs, we focused on miR-199a-5p miR-375. report that enforced promotes CTX resistance, whereas silencing sensitizes same drug. The ability miR-375 target PHLPP1 (PH domain leucine-rich repeat protein phosphatase 1), tumor suppressor negatively regulates AKT pathway, accounts, at least part, for drug-resistance activity. Indeed, restoration increases sensitivity rev...
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