Chronological Aging in Saccharomyces cerevisiae
作者： Valter D. Longo , Paola Fabrizio
DOI: 10.1007/978-94-007-2561-4_5
关键词:
摘要: The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life span (CLS) and replicative (RLS). is a measure of mean maximum survival time non-dividing yeast populations while based on number daughter cells generated by an individual mother cell before division stops irreversibly. Here we review principal discoveries associated with how they contributing understanding process molecular mechanisms that may lead healthy mammals. We will focus regulation Tor/Sch9 Ras/adenylate cyclase/PKA pathways particular emphasis those implicating age-dependent oxidative stress DNA damage/repair .
springer.com
springerlink.com参考文章(112)
Yong Pan, Gerald S. Shadel, Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY). ,vol. 1, pp. 131- 145 ,(2009) , 10.18632/AGING.100016
V.D. Longo, P. Fabrizio, Regulation of longevity and stress resistance: A molecular strategy conserved from yeast to humans? Cellular and Molecular Life Sciences. ,vol. 59, pp. 903- 908 ,(2002) , 10.1007/S00018-002-8477-8
Valter D. Longo, Joshua Mitteldorf, Vladimir P. Skulachev, Programmed and altruistic ageing. Nature Reviews Genetics. ,vol. 6, pp. 866- 872 ,(2005) , 10.1038/NRG1706
Cheol-Koo Lee, Roger G Klopp, Richard Weindruch, Tomas A Prolla, Gene Expression Profile of Aging and Its Retardation by Caloric Restriction Science. ,vol. 285, pp. 1390- 1393 ,(1999) , 10.1126/SCIENCE.285.5432.1390
Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward, PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS Nature. ,vol. 370, pp. 527- 532 ,(1994) , 10.1038/370527A0
N.P. D'mello, A.M. Childress, D.S. Franklin, S.P. Kale, C. Pinswasdi, S.M. Jazwinski, Cloning and characterization of LAG1, a longevity-assurance gene in yeast. Journal of Biological Chemistry. ,vol. 269, pp. 15451- 15459 ,(1994) , 10.1016/S0021-9258(17)40700-9
Scott Ogg, Suzanne Paradis, Shoshanna Gottlieb, Garth I. Patterson, Linda Lee, Heidi A. Tissenbaum, Gary Ruvkun, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature. ,vol. 389, pp. 994- 999 ,(1997) , 10.1038/40194
Jan Vijg, Aging of the Genome: The Dual Role of DNA in Life and Death ,(2007)
Alberto Diaspro, Vanessa N Moy, Valter D Longo, Edith Butler Gralla, Paola Fabrizio, Lee-Loung Liou, Joan Selverstone Valentine, SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. ,vol. 163, pp. 35- 46 ,(2003) , 10.1093/GENETICS/163.1.35
M Werner-Washburne, E Braun, G C Johnston, R A Singer, Stationary phase in the yeast Saccharomyces cerevisiae. Microbiological Research. ,vol. 57, pp. 383- 401 ,(1993) , 10.1128/MR.57.2.383-401.1993