Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress.

摘要: Objectives  Cisplatin-induced nephrotoxicity is the main cause for its dose-limited use in treatment of various cancers and results acute renal cell injury through generation reactive oxygen species. Chrysin possess antioxidant, anti-inflammatory anti-cancer properties. The aim this study was to investigate protective efficacy chrysin against cisplatin-induced nephrotoxicity. Methods  Thirty male Wistar rats were divided into five groups with six each group. Group I served as control received corn oil (vehicle chrysin) 14 days 0.9% saline cisplatin) on day only. II a single intraperitoneal injection cisplatin 14. III IV pretreated two different doses addition group V Rats examined effect induced depletion antioxidant enzymes, induction lipid peroxidation DNA damage kidney, utilizing well-established model nephropathy. Key findings  Pretreatment significantly attenuated oxidative by diminishing toxicity markers, such creatinine blood urea nitrogen, xanthine oxidase activity, accompanied increase enzymatic (catalase, glutathione peroxidase, reductase glutathione-S-transferase) non-enzymatic (reduced glutathione) status. Histological findings further substantiated chrysin, which reduced damage. Conclusions  data present suggest that effectively suppress ameliorating stress.