Evidence for a pathogenic linkage between glomerular hypertrophy and sclerosis.

摘要: Primary renal disease of immunologic or nonimmunologic mechanisms induces loss substantial nephron population. It is presumed that the initial functioning nephrons causes alterations function and metabolism in remnant nephrons, which per se are self-inflictive, leading to further nephrons. The ultimate outcome this vicious cycle end-stage kidney. potential role various pathophysiologic has been explored. These studies have shown a tight link between glomerular hypertrophy sclerosis. Analysis individual glomeruli show biphasic pattern these two parameters. Early development sclerosis takes place along with glomerulus, advancement occurs shrinkage size. Thus, we propose that, after loss, exposed increased growth-promoting factors, self-inflictive nature due their capacity produce excessive amounts extracellular matrix mesangial area. When obliterates capillary lumen, typical sclerotic lesion appears. This accelerating process, since reduction population, thereby imposing greater influence factors even on initially resistant.