Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement.
作者： Xiugao Feng , Xiangjin Xu , Yue Wang , Zhiyong Zheng , Guiying Lin
DOI: 10.1155/2015/316421
关键词:
摘要: Introduction. Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases. This study aims to investigate hip synovial tissues ankylosing spondylitis (AS) patients for plasma cells ectopic with germinal centers (GCs). Methods. Synovial samples were collected from 7 AS who received total replacement evaluated using immunohistochemistry CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic (FDC), CD38+ cells. Furthermore, immunoglobulin G (IgG IgG4), IgA, IgM, complement components C3d C4d synovia evaluated. Both FDCs IgG4-producing analyzed. Results. All seven had severe fibrosis. Massive infiltrations lymphocytes found 5 out patients' synovia. FDC networks observed coincidentally two Conclusion. The pathophysiological mechanism damage might be related coincidental tissue network identified here first time inflamed tissue.
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