Impaired cerebral microcirculation in isolated REM sleep behaviour disorder.

摘要: During the prodromal period of Parkinson's disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as locus coeruleus, caudal raphe nucleus, substantia nigra, forebrain nucleus basalis Meynert. Besides their involvement in regulation mood, sleep, behaviour, memory functions, these nuclei also innervate parenchymal arterioles capillaries throughout cortex, possibly ensure that oxygen supplies are adjusted according needs neural activity. The aim this study was examine whether patients with isolated REM sleep behaviour disorder, a parasomnia considered be phenotype α-synucleinopathies, reveal microvascular flow disturbances consistent disrupted central blood control. We applied dynamic susceptibility contrast MRI characterize microscopic distribution cerebral cortex 20 polysomnographic-confirmed disorder (17 males, age range: 54-77 years) 25 healthy matched controls (25 58-76 years). Patients were cognitively tested by Montreal Cognitive Assessment Mini Mental State Examination. Results revealed profound hypoperfusion compared controls. In patients, seen cortical areas associated language comprehension, visual processing recognition impaired cognitive performance. conclude abnormalities, related neurogenic control, present dysfunction. hypothesize pharmacological restoration perivascular neurotransmitter levels could help maintain function parkinsonism.