The misoprostol third stage of labour study : a randomised controlled comparison between orally administered misoprostol and standard management

摘要: Objective To compare misoprostol with standard oxytocic regimens in the prevention of postpartum haemorrhage. Design Randomised controlled trial. Setting Obstetric unit a large teaching hospital. Methods One thousand women randomised to 500 μg given orally or oxytocin, oxytocin ergometrine, ergometrine. Main outcome measures Incidence haemorrhage and incidence severity side effects. Results Postpartum occurred 12% 11% drugs (relative risk (RR) 1.10, 95% confidence interval (CI) 0.79, 1.55). Blood loss 1000 mL more 2% each group. Nausea, headache, dizziness tiredness were less frequent (RR (95% CI) 0.71 (0.59, 0.84); 0.53 (0.38, 0.74); 0.73 (0.61, 0.87) 0.88 (0.83, 0.94) respectively). The main effects shivering 1.95, CI 1.69, 2.25) rise temperature (difference mean 0.34°C, 0.26, 0.42). Conclusion Oral for was comparable oxytocics. Many common but pyrexia common. Larger trials are needed before establishing equivalence between haemorrhage.