Significant loss of bone mass in patients with early, active ankylosing spondylitis: a followup study.

摘要: Objective To analyze whether inflammatory disease activity plays a substantial role in the loss of bone mass observed ankylosing spondylitis (AS) patients who have not yet developed ankylosis. Methods A longitudinal cohort study 34 with early AS (duration <10 years) without ankylosis was conducted. The mean followup 19 months. Loss defined regions lumbar spine and femoral neck analyzed by dual x-ray absorptiometry. Patients were grouped according to biologic parameters (erythrocyte sedimentation rate or C-reactive protein level). Group 1 consisted 14 active disease; group 2 comprised 20 inactive disease. Serum levels interleukin-6 (IL-6) hormones (sex, thyroid, calciotropic), vertebral mobility (Schober test), daily physical activity, treatment administered recorded every 6 months for all patients. Results At end period, showed significant reduction (mean 1.01 gm/cm2 at entry versus 0.961 [P = 0.005]) (0.849 0.821 0.015]), which represented losses 5% 3%, respectively. In contrast, no AS. As expected, serum IL-6 significantly higher than those ± SD 8.3 9 pg/ml 2.8 5 0.008]). No differences between groups any other variables analyzed. Conclusion The observation that occurred only persistent strongly suggests itself major pathophysiology mineral disorders these patients.