Hybrid Polymeric Nanoparticles: Potential Candidate for Ophthalmic Delivery
作者： Dhruba J Bharali , Donald Armstrong , Shaker A Mousa , None
DOI: 10.1007/978-1-62703-475-3_18
关键词:
摘要: Nanotechnology that deals with submicron particles has the potential to deeply impact ophthalmic delivery owing its ability transport incorporated active ingredient/drugs different compartments of eye while protecting them from any external assault. Polymeric nanoparticles, in particular hybrid nanoparticles made up biodegradable and biocompatible polymers, revolutionize ocular carrier systems by taking advantage their highly tunable physicochemical properties. Here we report a synthesis method chitosan-poly(lactide-co-glycolide) (PLGA, as building block nanocarrier) for delivery. The method, characterization, uptake study retinal epithelial cells confocal imaging is described herein.
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sci-hub.st 参考文章(18)
Rubiana Mainardes, Maria Urban, Priscila Cinto, Najeh Khalil, Marco Chaud, Raul Evangelista, Maria Daflon Gremiao, Colloidal carriers for ophthalmic drug delivery. Current Drug Targets. ,vol. 6, pp. 363- 371 ,(2005) , 10.2174/1389450053765914
A LUDWIG, The use of mucoadhesive polymers in ocular drug delivery. Advanced Drug Delivery Reviews. ,vol. 57, pp. 1595- 1639 ,(2005) , 10.1016/J.ADDR.2005.07.005
Jean-Louis Bourges, Sandrine E. Gautier, Florence Delie, Riad A. Bejjani, Jean-Claude Jeanny, Robert Gurny, David BenEzra, Francine F. Behar-Cohen, Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Investigative Ophthalmology & Visual Science. ,vol. 44, pp. 3562- 3569 ,(2003) , 10.1167/IOVS.02-1068
Ramesh C Nagarwal, Shri Kant, PN Singh, P Maiti, JK Pandit, None, Polymeric nanoparticulate system: a potential approach for ocular drug delivery. Journal of Controlled Release. ,vol. 136, pp. 2- 13 ,(2009) , 10.1016/J.JCONREL.2008.12.018
Jae Hyung Park, Gurusamy Saravanakumar, Kwangmeyung Kim, Ick Chan Kwon, Targeted delivery of low molecular drugs using chitosan and its derivatives Advanced Drug Delivery Reviews. ,vol. 62, pp. 28- 41 ,(2010) , 10.1016/J.ADDR.2009.10.003
Himanshu Gupta, Mohammed Aqil, Roop K Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal, None, Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery Nanomedicine: Nanotechnology, Biology and Medicine. ,vol. 6, pp. 324- 333 ,(2010) , 10.1016/J.NANO.2009.10.004
J VASIR, V LABHASETWAR, Biodegradable nanoparticles for cytosolic delivery of therapeutics. Advanced Drug Delivery Reviews. ,vol. 59, pp. 718- 728 ,(2007) , 10.1016/J.ADDR.2007.06.003
Avinash Budhian, Steven J. Siegel, Karen I. Winey, Controlling the in vitro release profiles for a system of haloperidol-loaded PLGA nanoparticles International Journal of Pharmaceutics. ,vol. 346, pp. 151- 159 ,(2008) , 10.1016/J.IJPHARM.2007.06.011
Ning Li, Chunyang Zhuang, Mi Wang, Xiyang Sun, Shufang Nie, Weisan Pan, Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. International Journal of Pharmaceutics. ,vol. 379, pp. 131- 138 ,(2009) , 10.1016/J.IJPHARM.2009.06.020
Manuela Raviña, Patrizia Paolicelli, Alejandro Sanchez, Begoña Seijo, Maria Jose Alonso, Maria de la Fuente, Chitosan-based nanostructures: A delivery platform for ocular therapeutics Advanced Drug Delivery Reviews. ,vol. 62, pp. 100- 117 ,(2010) , 10.1016/J.ADDR.2009.11.026