Nonsense Mediated Decay Resistant Mutations Are a Source of Expressed Mutant Proteins in Colon Cancer Cell Lines with Microsatellite Instability
作者： David S. Williams , Matthew J. Bird , Robert N. Jorissen , Yen Lin Yu , Franscesa Walker
DOI: 10.1371/JOURNAL.PONE.0016012
关键词:
摘要: Background Frameshift mutations in microsatellite instability high (MSI-High) colorectal cancers are a potential source of targetable neo-antigens. Many nonsense transcripts subject to rapid degradation due nonsense-mediated decay (NMD), but with cMS the last exon or near exon-exon junction have intrinsic resistance (NMD). NMD-resistant therefore likely expressed mutant proteins MSI-High tumours.
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