Effect of Antimetabolites on Epidermal Structures
作者： DAVID S. NURSE
DOI: 10.1001/ARCHDERM.1963.01590140120019
关键词:
摘要: Methotrexate, 5-fluorouracil (5-FU), and 6-mercaptopurine (6-MP) have been tested for action on epidermal structures following topical application. 5-FU 6-MP inhibit rabbit hair regrowth, applied to human skin under suitable occlusive dressings produces erosion pigmentation of normal clearing psoriatic plaques. These processes studied microscopically, showing specific effects cells with little inflammatory reaction. Methotrexate has shown no in these situations, the possible reasons this are discussed.
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