The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression.

摘要: Background Chronic vagus nerve stimulation (VNS) is effective in the management of treatment-resistant epilepsy. Open-trial evidence suggests that VNS has clinically significant antidepressant effects some individuals who experience major depressive episodes. However, limited information regarding on neurocognitive performance exists. Objective The primary aim this study was to determine whether leads deterioration. Method A neuropsychological battery administered 27 patients with depression before and after 10 weeks VNS. Thirteen tests sampled domains motor speed, psychomotor function, language, attention, memory, executive function. Results No deterioration any measure detected. Relative baseline, improvement speed (finger tapping), function (digit-symbol test), language (verbal fluency), functions (logical reasoning, working response inhibition, or impulsiveness) found. For measures, improved correlated extent reduction symptoms, but output current not related changes cognitive performance. Conclusions Vagus may result enhanced primarily among show clinical improvement. Controlled investigation needed rule out contribution practice effects.