Natural Products with Antiprotozoal Activity

摘要: Protozoal diseases are a major threat to the health of human populations and domestic animals worldwide, mainly due absence vaccines deficiencies in chemotherapy vector control. Although has played role treatment control protozoal since pioneering work Ehrlich at beginning twentieth century, there remains wide variation efficacy available drugs. Several advances antiprotozoal have been achieved this some following development synthetic drugs for example quinolines, diaminopyrimidines triazenes malaria toxoplasmosis, organometallic diamidines trypanosomiasis leishmaniasis, 5nitroimidazoles amoebiasis, giardiasis trichomoniasis hydroxy-naphthoquinones theileriosis (Croft, 1997). Natural products also made an important impact. The polyene antibiotic ionophores monensin, lasalocid, narasin salinomycin, widely used prophylaxis avian coccidiosis, amphotericin B, is given leishmaniasis forms amoebiasis. aminoglycoside-aminocyclitol paromomycin (aminosidine) increasingly while tetracyclines clindamycin part armoury malaria. Quinine, identified as active ingredient Cinchona bark 1820, still extensively therapy, artemisinin (Qinghaosu), compound Artemisia annua, (Asteraceae), considered be most promissing lead amongst new antimalarial Emetine, isolated from rhizome root Cephaelis ipecacuanha, (Rubiaceae) 1828 was many years although now replaced by it’s derivative dehydroemetine.