Overview of direct oral anticoagulant therapy reversal.

摘要: Purpose Strategies for the management of bleeding complications and facilitation an invasive procedure in patients receiving direct oral anticoagulants (DOACs) are reviewed. Summary The DOACs provide clinical advantages versus vitamin K antagonists, including fixed dosing with no routine coagulation monitoring evidence a lower risk bleeding. However, as all anticoagulants, there is DOACs, so urgent reversal their anticoagulant activity may be required spontaneous or traumatic events undergoing emergency procedures. Reversal strategies dependent on involved, location severity bleeding, and/or urgency procedure. recently approved specific agent dabigatran, idarucizumab, together other agents development will hopefully allow emergent without increasing underlying thrombosis. research to determine optimal use these agents, terms choice agent, dosing, concomitant management. A systematic approach implementation hospitals also ensure that physicians, nurses, pharmacists receive appropriate education have necessary protocols guidelines manage situations. Conclusion DOAC need tailored involved well situation. should help facilitate anticoagulation who require surgery, though agents.