QUARTAN MALARIAL NEPHROTIC SYNDROME

摘要: Abstract 63 Nigerian children with the nephrotic syndrome were subjected to similar clinical and pathological investigations, in 42 immunofluorescence microscopy of renal-biopsy specimens was done. Most patients between four eight years old, had quartan malarial infection, poorly selective proteinuria, did not respond treatment. sections could be assigned any conventional categories for childhood, but showed a combination features which seemed typical childhood Nigeria designated " nephropathy (Q.M.N.). The characteristic lesion consists capillary-wall thickening segmental glomerular sclerosis leads progressive damage secondary tubular atrophy. Cellular proliferation is inconspicuous or absent. Cases Q.M.N. graded I, II, III according extent severity renal lesion. Ultramicroscopic examination confirmed that essentially due increased amounts basement-membrane-like material, arranged plexiform manner subendothelial region. An apparently unique feature presence small lacunae scattered throughout basement membrane, often containing islands material density membrane. Globulin deposits granular, mixed, diffuse patterns detected on all 1 examined antihuman globulin, occurred along Plasmodium malariœ antigen 10 cases. Correlation clinical, pathological, immunological findings show 12 non-Q.M.N. cases mainly highly granular mixed pattern fluorescence, most responded well In grade fluorescence more frequently associated response treatment than pattern, while invariably poor grades II III, uniformly irrespective selectivity proteinuria appearances. this study are consistent hypothesis an immunologically mediated disorder initiated by infection which, once established, pursues course.