Zwei oder vier Stunden [18F]FMISO-PET in Kopf-Hals-Karzinomen:

摘要: [18F]Fluoromisonidazole positron emission tomography (FMISO-PET) is a non invasive imaging technique that can assist detecting intra tumour regions of hypoxia. FMISO-PET evinces comparatively low signal-to-noise-ratio (SNR) and may be acquired dynamically or after different uptake times post injection (p.i.). The aim this study was to identify, if static images two hours (MISO2) four (MISO4) p.i. reveal higher contrast. Patients, methods: As part prospective trial, 23 patients with cancers the head neck underwent [18F]fluorodeoxyglucose (FDG) PET before during curative radiochemotherapy. Additionally, studies 2 h 4 were done treatment mean dose 11Gy, 23Gy 57Gy RCT. After coregistration, dedicated software used define gross volume (GTV) by FDG for primary tumour. This overlaid FMISO hypoxia within GTV determined. contrast between determined MISO2 MISO4 investigated analysed Wilcoxon-matched-pairs test. Results: Mean SUVmax in tumours all examinations 2.2 (stdev: 0.4, min: 1.3, max: 3.4) 2.4 0.7, 1.1, 4.4) h. In musculature 1.5 at both time points SUVmean decreased from 1.2 1.1 h, respectively. These effects resulted significantly rising ratios MISO4. differently defined contrasts revealed values (p < 0.002). Conclusion: Data acquisition [18F]FMISO should gather optimal contrast, preferably allowing further analysis, e. g. hypoxic sub definition therapy planning.