PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
作者： Morten Busk , Steen Jakobsen , Michael R. Horsman , Lise S. Mortensen , Ane B. Iversen
DOI: 10.3109/0284186X.2013.815797
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摘要: AbstractBackground. Tumor hypoxia contributes to loco-regional failure, and for optimal treatment planning, knowledge about tumor in individual patients is required. Nitroimidazole-based tracers, which are retained hypoxic cells, allow PET-based assessment of hypoxia, but current tracers characterized by slow tracer retention clearance, resulting low inter-tissue contrast. Pimonidazole an immune detectable marker widely used detection samples. has excellent chemical properties imaging, labeling non- invasive assay not been attempted. Here we labeled pimonidazole with 18F ([18F]FPIMO). Material methods. [18F]FPIMO was produced fluorination 1-[2-O-tosyl-3-(2-nitroimidazole-1-yl)-propyl]-piperidine, resulted two isomeric interchangeable forms (named “5” “6”) a radiochemical purity 91–100%. tested incubation different cell lines at high oxyge...
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