Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

作者: Erik O. Pettersen , Peter Ebbesen , Roben G. Gieling , Kaye J. Williams , Ludwig Dubois

DOI: 10.3109/14756366.2014.966704

关键词: PathologyDrug developmentCancer cellPopulationCancer researchBiologyIn vitroHypoxia (medical)Radiation therapyUnfolded protein responseChemotherapy

摘要: The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the …

参考文章(397)
Karen Block, Yves Gorin, David D. New, Assaad Eid, Tomasz Chelmicki, Amanda Reed, Goutam Ghosh Choudhury, Dipen J. Parekh, Hanna E. Abboud, The NADPH Oxidase Subunit p22 Inhibits the Function of the Tumor Suppressor Protein Tuberin The American Journal of Pathology. ,vol. 176, pp. 2447- 2455 ,(2010) , 10.2353/AJPATH.2010.090606
Huafeng Zhang, Marta Bosch-Marce, Larissa A. Shimoda, Yee Sun Tan, Jin Hyen Baek, Jacob B. Wesley, Frank J. Gonzalez, Gregg L. Semenza, Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia Journal of Biological Chemistry. ,vol. 283, pp. 10892- 10903 ,(2008) , 10.1074/JBC.M800102200
Kasper Toustrup, Brita Singers Sørensen, Marianne Nordsmark, Morten Busk, Carsten Wiuf, Jan Alsner, Jens Overgaard, Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer Cancer Research. ,vol. 71, pp. 5923- 5931 ,(2011) , 10.1158/0008-5472.CAN-11-1182
Mohan Doss, James J. Zhang, Marie-José Bélanger, James B. Stubbs, Eric D. Hostetler, Katherine Alpaugh, Hartmuth C. Kolb, Jian Q. Yu, Biodistribution and radiation dosimetry of the hypoxia marker 18F-HX4 in monkeys and humans determined by using whole-body PET/CT. Nuclear Medicine Communications. ,vol. 31, pp. 1016- 1024 ,(2010) , 10.1097/MNM.0B013E3283407950
Katarzyna J. Nytko, Nobuyo Maeda, Philipp Schläfli, Patrick Spielmann, Roland H. Wenger, Daniel P. Stiehl, Vitamin C is dispensable for oxygen sensing in vivo Blood. ,vol. 117, pp. 5485- 5493 ,(2011) , 10.1182/BLOOD-2010-09-307637
Jeffrey G. Dickhout, Rachel E. Carlisle, Danielle E. Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K. Garg, Ruma Banerjee, Randal J. Kaufman, Kenneth N. Maclean, Rui Wang, Richard C. Austin, Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. Journal of Biological Chemistry. ,vol. 287, pp. 7603- 7614 ,(2012) , 10.1074/JBC.M111.304576
L C J Baker, J K R Boult, S Walker-Samuel, Y-L Chung, Y Jamin, M Ashcroft, S P Robinson, The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function British Journal of Cancer. ,vol. 106, pp. 1638- 1647 ,(2012) , 10.1038/BJC.2012.131
Adrian M. Jubb, Francesca M. Buffa, Adrian L. Harris, Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. Journal of Cellular and Molecular Medicine. ,vol. 14, pp. 18- 29 ,(2010) , 10.1111/J.1582-4934.2009.00944.X
Jessica A. Bertout, Shetal A. Patel, M. Celeste Simon, The impact of O2 availability on human cancer Nature Reviews Cancer. ,vol. 8, pp. 967- 975 ,(2008) , 10.1038/NRC2540
Mirko Lehmann, Werner Baumann, Martin Brischwein, Hans-Jürgen Gahle, Ingo Freund, Ralf Ehret, Sabine Drechsler, Heiko Palzer, Martin Kleintges, Ullrich Sieben, Bernhard Wolf, Simultaneous measurement of cellular respiration and acidification with a single CMOS ISFET. Biosensors and Bioelectronics. ,vol. 16, pp. 195- 203 ,(2001) , 10.1016/S0956-5663(01)00123-3