Sodium arsenate and/or urea differently affect clinical attributes, hemato-biochemistry and DNA damage in intoxicated commercial layer birds
作者： Abdul Ghaffar , Riaz Hussain , Ghulam Abbas , Muhammad Nasir Ahmad , Akhtar Abbas
DOI: 10.1080/15569543.2017.1342096
关键词:
摘要: AbstractAn experimental study was ascertained in birds to assess the toxicological effects of arsenic (sodium arsenate) and urea alone or different combinations. After two weeks acclimatization, all were randomly divided into six equal groups (T0–T5) each containing 15 birds. Arsenic (A) (U) given chickens (mg/kg body weight) daily for 39 days as follow: T1 (A10U0.5), T2 (A15U0.75), T3 (A20U1.0), T4 (A25) T5 (U1.5). Various signs toxicity such depression, dullness, tremors, watery droppings, gasping, anemic comb wattle prominent treated Feed consumption weight with decreased significantly. The absolute relative weights visceral organs heart, liver, kidneys, spleen bursa Histologically, tissue sections liver showed necrosis hepatocyte, fatty degeneration mild congestion. Microscopically, renal t...
sci-hub.se 参考文章(52)
Zhang ZhiGang, Ge Ming, Zhang WeiQian, Yao ChunYu, Xue JiangDong, Liu Yan, Resveratrol reduces oxidative stress and improves arsenic efflux in rats exposed to arsenic trioxide. Pakistan Veterinary Journal. ,vol. 34, pp. 251- 253 ,(2014)
Radha Dutt Singh, Ratnakar Tiwari, Hafizurrahman Khan, Anoop Kumar, Vikas Srivastava, Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells Toxicology Letters. ,vol. 237, pp. 1- 10 ,(2015) , 10.1016/J.TOXLET.2015.05.014
Osama H. Elshenawy, Ayman O.S. El-Kadi, Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies. Toxicology Letters. ,vol. 238, pp. 17- 31 ,(2015) , 10.1016/J.TOXLET.2015.06.1646
R. Z. Abbas, Ahrar Khan, M. Z. Khan, Iftikhar Hussain, Rabia Sharaf, S. T. Gul, M. K. Saleemi, Fazal Mahmood, Arsenic induced toxicity in broiler chicks and its amelioration with ascorbic acid: Clinical, hematological and pathological study Pakistan Veterinary Journal. ,vol. 33, pp. 277- 281 ,(2013)
P C Nnabude, C D Ezeonyejiaku, M O Obiakor, J C Okonkwo, Eco-genotoxicology: Micronucleus Assay in Fish Erythrocytes as In situ Aquatic Pollution Biomarker: a Review - Journal of Animal Science Advances. ,vol. 2, pp. 123- 133 ,(2012)
Ahrar Khan, Rabia Sharaf, Muhammad Zargham Khan, Muhammad Kashif Saleemi, Fazal Mahmood, Arsenic induced toxicity in broiler chicks and its alleviation with ascorbic acid: a toxico-patho-biochemical study International Journal of Agriculture and Biology. ,vol. 15, pp. 1105- 1111 ,(2013)
G. Halder, B. Roy, G. Samanta, Haematologic aspects of arsenic intoxication with and without supplemental methionine and betaine in layer chicken Indian journal of poultry science. ,vol. 44, pp. 269- 272 ,(2009)
Mohammad Adil, Amit D Kandhare, Asjad Visnagri, Subhash L Bodhankar, None, Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α. Renal Failure. ,vol. 37, pp. 1396- 1407 ,(2015) , 10.3109/0886022X.2015.1074462
Umit Sener, Ramazan Uygur, Cevat Aktas, Emine Uygur, Mustafa Erboga, Gulseren Balkas, Veli Caglar, Bahadir Kumral, Ahmet Gurel, Hasan Erdogan, Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney Renal Failure. ,vol. 38, pp. 117- 123 ,(2016) , 10.3109/0886022X.2015.1103601
Mahfoud Messarah, Mongi Saoudi, Amel Boumendjel, Lilia Kadeche, Mohamed Salah Boulakoud, Abdelfattah El Feki, Green tea extract alleviates arsenic-induced biochemical toxicity and lipid peroxidation in rats. Toxicology and Industrial Health. ,vol. 29, pp. 349- 359 ,(2013) , 10.1177/0748233711433934