Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

摘要: We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced arsenic in rats. have used 24 male Sprague-Dawley Rats were divided into three groups. Physiological serum 10 mL/kg dose as intragastric was given control group. Sodium arsenite (10 mg/kg, gavage for fifteen days) TQ 15 + After days, animals' kidneys taken theirs, then we performed histological apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities malondialdehyde (MDA) levels examined oxidative stress parameters. determined arsenic. Increased renal injury cells been detected Degenerative changes group diminished. Although MDA augmented group, SOD, CAT GSH-Px lessened than other Our findings suggest that may impede stress, damaged also generation arisen from plays a arsenic-induced toxicity potentially be remedial agent.