Loss of plasma membrane integrity, complement response and formation of reactive oxygen species during early myocardial ischemia/reperfusion

摘要: Loss of plasma membrane integrity (LPMI) is a hallmark necrotic cell death. The involvement complement and ROS in the development LPMI during early stages murine myocardial ischemia-reperfusion injury was investigated. developed within 1 h reperfusion to level that sustained through 24 h. C3 deposition became significant at 3-h thus contributed little prior this time. SOD1 transgenic mice had significantly less compared with WT but not later time points. Catalase were protected from 1-h mice, 69% reperfusion. This protection transient. At 24-h catalase identical mice. delayed benefits over-expressed are consistent its antioxidant action downstream SOD1. onset occurs maintained contribute first 3 reperfusion, while deposition, which becomes after may thereafter.