The effect of superoxide dismutase and catalase on myocardial reperfusion injury in the isolated rat heart.
作者： Yasuyuki Nishikawa , Shinichiro Yamamoto , Keiji Ataka , Kazuo Nakamura
DOI: 10.1007/BF02470970
关键词:
摘要: This study was designed to evaluate the efficacy of superoxide dismutase (SOD) and catalase on ischemic reperfusion injury in isolated working rat heart. The temperature duration ischemia varied under three conditions: 1) at 37°C for 35 minutes, 2) 28°C 120 minutes 3) 20°C minutes. SOD (100 mg/L) (10 were either added St. Thomas' Hospital cardioplegic solution during (CP group) or 10 after reflow (RS group). They compared with a control group which received no free radical scavengers. postischemic recovery ratio cardiac functions markedly superior values significant difference being noted CP RS groups 28°C. In series done 20°C, improvement seen group, also showed better functional rates although differences not statistically significant. Thus, fluid demonstrated an excellent protective effect myocardium against both hypothermic normothermia.
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