T cell receptors with improved pairing
作者： Jens Fritsche , Sebastian Bunk , Dominik Maurer , Claudia Wagner , Franziska Hoffgaard
DOI:
关键词:
摘要: The present invention relates to modified T cell receptor (TCR) α or β chains, heterodimers comprising the same, wherein in variable domain of said chain, an amino acid at position 44 according IMGT numbering is substituted by another suitable order improve pairing desired chains.
lens.org 参考文章(78)
Randall A. Hughes, Aleksandr E. Miklos, Andrew D. Ellington, Gene synthesis: Methods and applications Methods in Enzymology. ,vol. 498, pp. 277- 309 ,(2011) , 10.1016/B978-0-12-385120-8.00012-7
Thomas Hoffmann, Angela M. Krackhardt, Iris Antes, Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition PLOS Computational Biology. ,vol. 11, pp. e1004244- ,(2015) , 10.1371/JOURNAL.PCBI.1004244
Toni Weinschenk, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Colette Song, Steffen Walter, Norbert Hilf, Harpreet Singh, Personalized immunotherapy against several neuronal and brain tumors ,(2014)
Toni Weinschenk, Harpreet Singh, Jens Fritsche, Andrea Mahr, Biomarkers for predicting the efficacy of an immunotherapy against cancer ,(2011)
Toni Weinschenk, Harpreet Singh, Oliver Schoor, Claudia Trautwein, Peter Lewandrowski, Norbert Hilf, Steffen Walter, Composition of tumour-associated peptides and related anti-cancer vaccine ,(2008)
Toni Weinschenk, Jens Fritsche, Method for differentially quantifying naturally processed hla-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development ,(2011)
Toni Weinschenk, Peter Lewandrowski, Cecile Gouttefangeas, Hans Georg Rammensee, Stefan Stevanovic, Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof ,(2010)
Toni Weinschenk, Harpreet Singh, Niels Emmerich, Steffen Walter, Tumor-associated peptides binding to human leukocyte antigen (hla) class i or ii molecules and related anti-cancer vaccine ,(2006)
Toni Weinschenk, Cécile Gouttefanges, Hans-Georg Rammensee, Peter Lewandrowski, Stefan Stevanovic, Novel and powerful mhc-class ii peptides derived from survivin ,(2009)