Role of T cell TGF-β signaling in intestinal cytokine responses and helminthic immune modulation

摘要: Colonization with helminthic parasites induces mucosal regulatory cytokines, like IL-10 or TGF-beta, that are important in suppressing colitis. Helminths induce T cell secretion and regulate lamina propria mononuclear (LPMC) Th1 cytokine generation an IL-10-dependent manner WT mice. also stimulate TGF-beta release. As exerts major effects on lymphocytes, we investigated the role of lymphocyte signaling modulation intestinal immunity. is interrupted receptor II dominant negative (TGF-betaRII DN) mice by T-cell-specific over-expression a TGF-betaRII DN. We studied LPMC responses DN were uninfected colonized nematode, Heligmosomoides polygyrus. Our results indicate essential limiting Th2 responses. Furthermore, demonstrate induction requires intact TGF-beta-signaling pathway. fail to curtail robust, dysregulated production chronic colitis Thus, for stimulation production, IFN-gamma H. polygyrus-mediated suppression