A latent class analysis of parental bipolar disorder: Examining associations with offspring psychopathology.

摘要: Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need intervention. Additionally, have implications for offspring risk. First, latent class analysis (LCA) categorized parents BD based on salient illness characteristics: type, onset age, polarity index episode, pole majority episodes, rapid cycling, psychosis, anxiety comorbidity, substance dependence. Fit indices favored three parental classes some substantively meaningful patterns. Two classes, labeled "Earlier-Onset Bipolar-I" (EO-I) Bipolar-II" (EO-II), comprised who had a mean age mid-adolescence, EO-I primarily BD-I EO-II entirely BD-II parents. The third class, "Later-Onset BD" (LO) an average adulthood. Classes also varied probability dependence, episodes. Second, we examined rates disorders (ages 4-33, Mage=13.46) membership. Differences emerged only such that higher rates, compared to LO parents, particularly daughters. Findings may enhance understanding its nosology.