Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4)).

摘要: The EU REACH legislation for chemicals of 2006 represents the largest investment into consumer product safety ever. A reanalysis cost and animal use estimates was carried out based on final legislation, test guidance industry published by European Chemical Agency, preregistration completed in December 2008. new number substances falling under range from 68 to 101,000 chemicals, substantially exceeding earlier 29,000 substances. latter were, however, data before 1994 both expansion growth chemical since have contributed higher numbers today. lower estimate 68,000 through current testing requirements with due regard emerging alternative approaches, using all cases most optimistic assumptions (minimal per neglecting triggering additional tests confirmatory (re-)tests as well requested but not yet defined endocrine disruption, respiratory irritation, sensitization developmental neurotoxicity). demanding studies are area reproductive toxicity about 90% 70% required costs registration. overall result suggests a demand 54 million vertebrate animals 9.5 billion euro. This clearly challenges feasibility program without major high-throughput methodologies.