Rapid detection of pesticides not amenable to multi-residue methods by flow injection–tandem mass spectrometry

摘要: Flow injection combined with tandem mass spectrometry (MS/MS) was investigated for the rapid detection of highly polar pesticides that are not amenable to multi-residue methods because they do partition into organic solvents and require dedicated chromatographic conditions. The included in this study were amitrole, chlormequat, cyromazine, daminozide, diquat, ethephon, fosetyl-Al, glufosinate, glyphosate its metabolite aminomethylphosphonic acid, maleic hydrazide, mepiquat paraquat. composition flow-injection solvent optimized achieve maximum MS/MS sensitivity. Instrumental limits varied between <0.05 1 pg. Fruit, vegetable, cereal, milk kidney samples extracted water (1 % formic acid case paraquat/diquat) ten times diluted either methanol/0.1 % ammonia or acetonitrile/0.1 % ammonia, depending on pesticide. ion suppression observed depended strongly both matrix This could be largely compensated by matrix-matched calibration, but more accurate quantification obtained using isotopically labelled standards (commercially available most studied). method ranged from 0.02 mg/kg chlormequat 2 mg/kg hydrazide 0.05–0.2 mg/kg other pesticide/matrix combinations. sufficiently low test compliance EU residue many relevant pesticide/commodity substantially reduces liquid chromatography–MS/MS capacity demand which laboratories is prohibitive inclusion these their monitoring surveillance programmes.