A molecular model of the Vibrio cholerae cytolysin transmembrane pore
作者： Sergio Pantano , Cesare Montecucco
DOI: 10.1016/J.TOXICON.2005.09.007
关键词:
摘要: The cytotoxic activity of some the most pathogenic strains Vibrio cholerae is associated with a cytolysin protein (VCC), which forms oligomeric transmembrane pores and changes permeability intestinal cells. We present here model structure pore VCC based on sequence comparison other pore-forming toxins. suggested to form β-barrel relatively large trans vestibule region. Calculations electrostatic profile within lumen provide rationale for low conductance selectivity ion channel.
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