Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
作者： M Miwa , M Ura , M Nishida , N Sawada , T Ishikawa
DOI: 10.1016/S0959-8049(98)00058-6
关键词:
摘要: … Cytidine (Cyd) deaminase was located in high concentrations in the liver and various types … to an HPLC equipped with an ultraviolet detector operated at 280 nm. The HPLC column and …
elsevier.com
sci-hub.se 参考文章(18)
Thomas A. Krenitsky, Jane W. Mellors, Ralph K. Barclay, Pyrimidine Nucleosidases Journal of Biological Chemistry. ,vol. 240, pp. 1281- 1286 ,(1965) , 10.1016/S0021-9258(18)97572-1
Hideo Ishitsuka, Hiromi B. Maruyama, Keiko Fukuoka, Kenji Takemoto, Masanori Miwa, Akemi Itoga, Role of uridine phosphorylase for antitumor activity of 5'-deoxy- -5-fluorouridine. GANN Japanese Journal of Cancer Research. ,vol. 71, pp. 112- 123 ,(1980) , 10.20772/CANCERSCI1959.71.1_112
AKIRA KONO, YASUHIRO HARA, SETSURO SUGATA, YOSHIHARU KARUBE, YOSHIKAZU MATSUSHIMA, HIDEO ISHITSUKA, Activation of 5'-Deoxy-5-fluorouridine by Thymidine Phosphorylase in Human Tumors Chemical & Pharmaceutical Bulletin. ,vol. 31, pp. 175- 178 ,(1983) , 10.1248/CPB.31.175
Peter W. Woodman, Awni M. Sarrif, Charles Heidelberger, Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine. Cancer Research. ,vol. 40, pp. 507- 511 ,(1980)
Dah Hsi Wang Ho, Distribution of Kinase and Deaminase of 1-β-d-Arabinofuranosylcytosine in Tissues of Man and Mouse Cancer Research. ,vol. 33, pp. 2816- 2820 ,(1973)
Hiroyasu Baba, Takuma Sasaki, Kazuo Nitta, Mieko Takeuchi, Tomiko Tanaka, Nobuaki Uehara, Takehiko Kunimoto, The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors. Japanese Journal of Cancer Research. ,vol. 76, pp. 1034- 1041 ,(1985) , 10.20772/CANCERSCI1985.76.10_1034
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Shin-Ichi Watanabe, Takafumi Uchida, Expression of cytidine deaminase in human solid tumors and its regulation by 1 α,25-dihydroxyvitamin D3 Biochimica et Biophysica Acta. ,vol. 1312, pp. 99- 104 ,(1996) , 10.1016/0167-4889(96)00024-9
Yasuyuki Ninomiya, Masanori Miwa, Hiroyuki Eda, Hiroshi Sahara, Kaori Fujimoto, Masako Ishida, Isao Umeda, Kazuteru Yokose, Hideo Ishitsuka, Comparative Antitumor Activity and Intestinal Toxicity of 5′-Deoxy-5-fluorouridine and Its Prodrug Trimethoxybenzoyl-5′-deoxy-5-fluorocytidine Japanese Journal of Cancer Research. ,vol. 81, pp. 188- 195 ,(1990) , 10.1111/J.1349-7006.1990.TB02547.X
Y. Takebayashi, S.-i. Akiyama, S. Akiba, K. Yamada, K. Miyadera, T. Sumizawa, Y. Yamada, F. Murata, T. Aikou, Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma Journal of the National Cancer Institute. ,vol. 88, pp. 1110- 1117 ,(1996) , 10.1093/JNCI/88.16.1110