Acute ventilation-perfusion mismatching resulting from inhalative smoking of the first cigarette in the morning.

摘要: The effect of the first cigarette in morning on airway resistance (Raw) which can be measured by body-plethysmography was investigated 70 inhaling smokers. test population showed a significant (P<0.0005) fall Raw 8 min after smoking. A further study (n = 16) that most likely to attributable decrease trapped air. arterial blood gases and alveolar-arterial oxygen difference P(A-a)O2 carbon dioxide P(A-a)CO2 12 Smoking gave rise (P < 0.0005) partial pressure (PaO2) with compensatory overventilation. At same time, increased significantly (P<0.01 P<0.05, respectively). This could observed for up 24 In addition, flow pulmonary capillaries 28 subjects nitrous oxide method (\(\dot Q\)N2O) before, 18–22 after, smoking morning. After smoking, there \(\dot Q\)N2O an average 11.3%. Rw PaO2 overventilation, increase are interpreted as manifestations pronounced acute ventilation-perfusion mismatching induced