Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex

作者: J. I-Ju Leu , Patrick Dumont , Michael Hafey , Maureen E. Murphy , Donna L. George

DOI: 10.1038/NCB1123

关键词:

摘要: … Interaction of p53 with Bak causes oligomerization of Bak and release of cytochrome c from … formation of the p53–Bak complex coincides with loss of an interaction between Bak and the …

参考文章(32)
Scott H. Kaufmann, Judith E. Karp, Phyllis A. Svingen, Stan Krajewski, Philip J. Burke, Steven D. Gore, John C. Reed, Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse Blood. ,vol. 91, pp. 991- 1000 ,(1998) , 10.1182/BLOOD.V91.3.991.991_991_1000
Francesco Pallotti, Giorgio Lenaz, None, Isolation and Subfractionation of Mitochondria from Animal Cells and Tissue Culture Lines Mitochondria, 2nd Edition. ,vol. 80, pp. 3- 44 ,(2007) , 10.1016/S0091-679X(06)80001-4
Francesco Pallotti, Giorgio Lenaz, Chapter 1 Isolation and subfractionation of mitochondria from animal cells and tissue culture lines Methods in Cell Biology. ,vol. 65, pp. 1- 35 ,(2001) , 10.1016/S0091-679X(01)65002-7
Gretchen S Jimenez, Monica Nister, Jayne M Stommel, Michelle Beeche, Erin A Barcarse, Xiao-Qun Zhang, Stephen O'Gorman, Geoffrey M Wahl, None, A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nature Genetics. ,vol. 26, pp. 37- 43 ,(2000) , 10.1038/79152
Jerry E Chipuk, Tomomi Kuwana, Lisa Bouchier-Hayes, Nathalie M Droin, Donald D Newmeyer, Martin Schuler, Douglas R Green, None, Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. ,vol. 303, pp. 1010- 1014 ,(2004) , 10.1126/SCIENCE.1092734
Christine K Bieszczad, Emily S Cleaveland, Jonathan P Park, Ruth W Craig, Thuluvancheri K Mohandas, Julie A Vrana, Yan Ma, An MCL1-overexpressing Burkitt Lymphoma Subline Exhibits Enhanced Survival on Exposure to Serum Deprivation, Topoisomerase Inhibitors, or Staurosporine but Remains Sensitive to 1-β-d-Arabinofuranosylcytosine Cancer Research. ,vol. 62, pp. 892- 900 ,(2002)
Atan Gross, Vamsi K. Mootha, Tullia Lindsten, Mona Ashiya, Craig B. Thompson, Michael C. Wei, Stanley J. Korsmeyer, Solly Weiler, tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c Genes & Development. ,vol. 14, pp. 2060- 2071 ,(2000) , 10.1101/GAD.14.16.2060
Michael C Wei, Wei-Xing Zong, Emily H-Y Cheng, Tullia Lindsten, Vily Panoutsakopoulou, Andrea J Ross, Kevin A Roth, Grant R MacGregor, Craig B Thompson, Stanley J Korsmeyer, Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Science. ,vol. 292, pp. 727- 730 ,(2001) , 10.1126/SCIENCE.1059108
Emily H-Y Cheng, Tatiana V Sheiko, Jill K Fisher, William J Craigen, Stanley J Korsmeyer, VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. ,vol. 301, pp. 513- 517 ,(2003) , 10.1126/SCIENCE.1083995
Yi-Te Hsu, Richard J. Youle, Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations Journal of Biological Chemistry. ,vol. 273, pp. 10777- 10783 ,(1998) , 10.1074/JBC.273.17.10777