46 – Alcohol, ALDH2 Genotypes and Intestinal Cancer

摘要: This chapter discusses the relationship between intestinal cancer and alcohol drinking ALDH2 gene. Epidemiological findings suggest that heterozygous are carriers of gene, which encodes an acetaldehyde-oxidizing enzyme, to be highly sensitive alcohol-induced esophageal cancer. indicates key substance in alcohol-related carcinogenesis is acetaldehyde, at least this organ. An examination was made whether scheme association can also applied Thus, three case-control studies on colorectal reported from Japan have tested for genotype difference. The results been similar, is, individuals a higher risk than normal homozygotes with excessive intake alcohol. Because past epidemiological Western countries rather inconsistent, probably less intensive, consumption incidence reported.