Роль неэтерифицированных жирных кислот в патогенезе сердечно-сосудистых заболеваний

摘要: The paper reviews publications concerned the role of nonesterifi ed fatty acids (NEFA) in pathogenesis cardiovascular diseases. NEFAs are four and more carbons chain length carbonic they presented free form (nonesterifi ed) human body. Plasma produced by adipose tissue triglyceride lipolysis, another source lipoproteins such as chylomicrons, very low density intermediate lipoproteins. Elevated NEFA concentrations plasma risk factor diseases type 2 diabetes mellitus independent hypertension sudden death. concentration is elevated atherosclerosis, acute myocardial infarction, mellitus, obesity, hypertension, often metabolic syndrome. A probable cause accumulation may be overeating physical activity, which result increase mass, lipolysis intensifi cation elevation plasma. a number conditions (abdominal atherogenic dyslipidemia, insulin resistance, endothelial dysfunction, vascular infl ammation, ischemic heart disease, rhythm disturbances, death) possible ways their correction discussed.