Elevated plasma fatty acid concentrations stimulate the cardiac autonomic nervous system in healthy subjects

摘要: Background: Fatty acids have been shown to stimulate the sympathetic nervous system in rats. Power spectral analysis of heart rate variability (HRV) is a safe and useful tool with which evaluate cardiac autonomic (ANS) activity. Whether changes plasma fatty acid concentrations affect or HRV humans unknown. Objective: We investigated possible after significant increase concentration. Design: Subjects were randomly assigned receive an infusion lipid emulsion (10% triacylglycerol for 180 min) + heparin (a bolus 200 U followed by 0.2 U.min -1 .kg body wt ; n = 20) 0.9% NaCl (for min; 10). Results: Lipid was associated rise epinephrine norepinephrine concentrations. The concentration decline RR interval (P < 0.03) total power 0.03). Analysis different components showed that stimulated low-frequency (LF) 0.03 at second hour P 0.01 third hour) inhibited high-frequency (HF) hours). Consequently, LF-HF ratio significantly hour). Such results persisted, although attenuated, when study repeated association propranolol (n 8). Conclusion: Elevated may