QTC INTERVAL (CARDIAC REPOLARIZATION) : LENGTHENING AFTER MEALS

摘要: NAGY, DAVID, RONALD DeMEERSMAN, DYMPNA GALLAGHER, ANGELO PIETROBELLI, ADRIENNE S ZION, DEBORAH DALY, STEVEN B HEYMSFIELD. QTc interval (cardiac repolarization): lengthening after meals. Weight reduction, either by dietary or surgical means, is associated with prolongation of the heart rate corrected QT (QTc=QT/R-R0–5 and, on occasion, sudden death. Screening subjects obesity before weight loss for prolonged intervals an accepted practice, although at present, there are no guidelines whether should be fasting electrocardiogram (EKG) evaluation. The aim this study was to test hypothesis that EKG duration independent meal ingestion. tested in 11 healthy who ingested a 500-kcal formula meal. A small decrease absolute and steady decline R-R were observed up 60 minutes increased above baseline 15 (p<0. 007) meal, change persisted 1-hour postmeal observation period. Spectral analysis (low-/high-frequency amplitude ratio) indicated cardiac autonomic flow did not lengthen low-/highfrequency ratio remained unchanged eight evaluated similar manner but whom isovolumic amounts water replaced These observations suggest (1) repolarization changes feeding, (2) influenced intake, (3) nervous system may play role meal-related changes. findings have implications evaluation patients starting during treatment.