The impacts of obesity on the cardiovascular and renal systems: cascade of events and therapeutic approaches.

摘要: There is a neglected epidemic of both obesity and metabolic syndrome in industrialized unindustrialized countries all over the globe. Both conditions are associated with high incidence other serious pathologies, such as cardiovascular renal diseases. In this article, we review potential underlying mechanisms by which promote hypertension, including changes cardiovascular–renal physiology induced leptin, sympathetic nervous system, renin–angiotensin–aldosterone insulin resistance, free fatty acids, natriuretic peptides, proinflammatory cytokines. We also discuss promotes conditions, well available nonpharmacologic pharmacologic approaches for treating obesity-induced hypertension. The findings presented herein suggest that adipocytes may be key regulator function.